ibioseminars 2012.3.5---Susan Wessler : Introduction to transposable elements

ibioseminars 2012.3.5---Susan Wessler : Introduction to transposable elements

Susan Wessler : Introduction to transposable elements
In Part 1, Wessler introduces transposable elements (TEs); small movable pieces of DNA that can insert throughout the genome. She describes their discovery in maize by Barbara McClintock in the 1940's and their impact on the current study of genetics. Wessler goes on to provide more details about TEs and transposase, the enzyme that facilitates insertion of TEs into the target DNA.

Amazingly, as much as 50% of a mammalian genome and much more of a plant genome can be made of TEs. In Part 2 of her talk, Wessler discusses work from her lab analyzing the impact of TEs on gene and genome evolution. By looking for and finding a TE currently undergoing rapid amplification, Wessler and her colleagues have been able to assess how a type of TE called a MITE can rapidly increase its copy number without killing its host, rice.

蘇珊Wessler：座子簡介
第1部分中，Wessler介紹座子（TES）;小型可移動的DNA片段，可以插入整個基因組。巴巴拉·麥克林托克在1940年和遺傳學研究的影響，玉米，她這樣描述他們的發現。 wessler提供有關跨國企業和轉座酶，有利於插入到目標DNA的TES更多細節。

令人驚訝的是，多達50％的哺乳動物的基因組，植物基因組可以工商業污水附加費。在她的談話中的第2部分，Wessler討論從分析基因和基因組進化的影響，跨國企業在她的實驗室工作。通過尋找並找到TE目前正在迅速放大，Wessler和她的同事們已經能夠評估如何一類的TE稱為蟎能迅速殺死其宿主，大米，其拷貝數增加。